INPROTEOLYS

Andrea Pichler

Research interest:

Crosstalk between SUMO and ubiquitin Our group is interested in the posttranslational modifications with ubiquitin and SUMO (small ubiquitin related modifier) which are important regulators for rapid and reversible changes in protein function. Modifications occur via ATP- dependent enzymatic cascades including E1, E2 and E3 enzymes. Recently, we identified a ubiquitin E2 enzyme as SUMO target. Biochemical analysis indicates that modification severely reduces the function of this particular enzyme. This opens up the intriguing possibility that inhibition of a ubiquitin E2, which potentially works (in concert) with several E3s, results in widespread consequences for the cell by influencing a large subset of substrates. The focus of our work is to investigate whether other ubiquitin E2 enzymes are sumoylated and what are the respective consequences.

E-mail		andrea.pichler@meduniwien.ac.at

Phone		+43 (0) 1 4277 61710

Address		Dr. Bohrg.9, A-1030 Vienna

Personal Web		http://www.mfpl.ac.at/index.php?cid=575

Curriculum Vitae		Andrea Pichler CV

Keywords		SUMO, ubiquitin, E2 conjugating enzymes