INPROTEOLYS

Rob Martin Frans Wolthuis

Research interest:

The goal of our laboratory is to understand how cell division works, both in normal and in cancer cells. Our main interests are to reveal the roles of Cyclin-Cdk’s in mitotic progression and to decipher the regulation of protein destruction in mitosis, critical to coordinate cell division and sister chromatid separation. Using mammalian cells as model systems, we continue to develop and apply a combinatorial approach of biochemistry, RNAi-genetics and automated live cell imaging.

Phone		+31-20-512 2095

Address		NKI (B7) Plesmanlaan 121, 1066CX Amsterdam, The Netherlands

Personal Web		http://www.nki.nl/Research/Faculty+and+Research/Divisions/Molecular+Carcinogenesis/Wolthuis.htm

Curriculum Vitae		-

Keywords		cell cycle, proteolysis, cyclin, Securin, Cdc20, APC/C.