INPROTEOLYS

Bernat Crosas

Research interest:

The goal of the lab is to examine novel levels of regulation of the proteasome pathway focusing on the mechanisms that control proteasome function and its interaction with protein substrates . Our ongoing studies pursue basic and translational research areas. Our objective is to characterize the regulatory interactions that control the process of protein degradation in the proteasome. We also aim to identify novel ubiquitin pathway substrates by means of an optimized biochemical fractionation of ubiquitin conjugates. The development of these projects will uncover mechanisms of action of the proteasome, which will be integrated in the comprehension of the role of the proteasome in cell physiology and molecular pathology. One of our priorities will be to reveal novel targets in the proteasome pathway for the design of drug therapies. The use of S. cerevisiae, the reference model in the ubiquitin-proteasome system, will allow us to address simultaneously biochemical, genetic, molecular and cell biology approaches in feasible time frames. Our final aim is to create a reference group specialized in proteasome functional characterization, in a moment in which a new era on proteasome research is emerging.

E-mail		bcnbmc@ibmb.csic.es

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Keywords		ubiquitin-proteasome pathway