INPROTEOLYS

Gemma Marfany

Research interest:

Our group has focused on the structural and functional characterisation of USP25, a gene located on human chromosome 21 that encodes a deubiquitinating enzyme (DUB). DUBs are important, yet relatively unkown, components of the ubiquitin/proteasome system that are able to hydrolise the ubiquitin covalently attached to a protein substrate. We have identified several specific substrates of USP25 in muscle tissue and we are currently characterising the regulation of USP25, both at the expression and protein levels.

E-mail		gmarfany@ub.edu

Phone		+34 93 4021502

Address		Departament de Genetica. Facultat de Biologia. Universitat de Barcelona. Avda. Diagonal, 645. (08028) Barcelona. SPAIN

Personal Web		http://www.ub.edu/genetica/humana/marfany.htm

Curriculum Vitae		-

Keywords		ubiquitin, deubiquitination, DUB, ubiquitin-specific protease, ubiquitin interacting domains.