INPROTEOLYS

José González Castaño

Research interest:

Protein turnover, transcriptional control and metabolic regulation in cellular and animal models of Parkinson Disease. Idiopathic Parkinson Disease (PD) is the most prevalent motor disturbance in the elderly. Three main pathogenetic mechanisms have been implicated in PD as playing a critical role in the dismay and death of dopaminergic neurons: protein aggregation, mitochondrial disfunction, and mutations in several genes (PARK) responsible of rare forms of familiar PD with autosomal inheritance. We are interested in the study of the role and regulation of protein-turnover, mainly through the ubiquitin-proteasome system, in the adaptive metabolic response and in the changes in transcription factors responsible of the differentiation and maintenance of dopaminergic neurons using cellular and animals models of PD generated by the expression of wild type and mutant versions of the PARK genes that has been described in the familiar forms of PD. The main goal is to understand the molecular and cellular mechanisms implicated in the stress response of dopaminergic neurons that promote its survival or death in order to find possible targets for therapeutic intervention that would ameliorate the conditions of PD patients

E-mail		joseg.castano@uam.es

Phone		34-914975427

Address		Departamento de Bioquímica. Lab B13. Facultad de Medicina UAM. Arzobispo Morcillo s/n. 28029 Madrid

Personal Web		-

Curriculum Vitae		-

Keywords		proteasome, ubiquitin, synuclein, PARK, Transcription factors, Parkinson