INPROTEOLYS

Luis C. Anton

Research interest:

We study the proteolytic events in the cytosol and the role they play supplying precursors to the MHC class I antigen processing pathway. Our aims are: 1) Identification of substrates of the ubiquitin/proteasome pathway, and determination of whether newly synthesized proteins constitute a significant fraction of these substrates. 2) Determination of the relationship between these substrates and peptides presented by MHC class I. 3) Identification of ubiquitin/proteasome-independent proteolytic pathways. Our data seem to discard the suggested role for the enzyme tripeptidyl peptidase II. Our data point instead to a prominent role of macroautophagy.

E-mail		lanton@cbm.uam.es

Phone		(34) 911 964 553

Address		Centro de Biologia Molceular Severo Ochoa, CSIC/UAM, C/ Nicolas Cabrera, 1, Cantoblanco, 28049 Madrid, Spain

Personal Web		-

Keywords