INPROTEOLYS

DNA damage checkpoint and caspase/proteasome regulation

Our group is interested in proteins that control the cell cycle delay in human cells after DNA damage and stalled
replication forks, mainly the ATR-Chk1 pathway. In the past years we learned that some components of this machinery are regulated by proteolysis: Claspin, a key mediator protein in the ATR-Chk1 pathway is an example of that: it is processed by caspases during apoptosis, but also regulated by the ubiquitin-proteasome pathway during the cell cycle, and also during apoptosis. We are pursuing in this studies on the precisse mechanism of how Claspin is regulated

Raimundo Freire

Silvana de Lorenzo

Ivan Mamely

Antonio J Perez

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