PROTEOLYSIS AND NEURODEGENERATION
LAST PRELIMINARY PROGRAME
4-7 of May 2010
FUNDACION RAMON ARECES
1 Opening conference
5 Oral Sessions and 2 Poster Sessions
14 long presentations (invited speakers)
18 short presentations (chosen among applicants)
1 Young Investigator Award Lecture
FINAL PROGRAM
May 4
16.00-17.30 Registration
17.30-18.00 Welcome by Prof. Julio R. Villanueva
(Fundación Areces)
Alberto Ferrús, Patricia Boya, Ana Ma. Cuervo, David Rubinsztein, Wiep Scheper, Manuel S. Rodríguez &
José G. Castaño
18.00- 19.00 L1 Opening conference by Sangram Sisodia
(University of Chicago)
Presenilin function in physiology and disease
19.00- 21.15 Welcome cocktail
May 5
Session I: Autophagy in neurodevelopment and ageing
Chair: Sangram S. Sisodia
9.00 - 9.40 OP1 Ana María Cuervo (Albert Einstein College) Selective autophagy dysfunction in aging: tales from an old loyal broom
9.40 - 10.20 OP2 Noboru Mizushima (Tokyo Medical University)
Physiological role of autophagy in mammals
10.20 - 11.00 OP3 Francesco Cecconi (University of Roma)
Ambra1 in the homeostasis of the nervous system
11.00 - 11.20 Coffee break
11.20-11.40 ST1 (P1) Marian Mellen (CIB CSIC)
New roles of autophagy during development
11.40-12.0 ST2 (P2) Zsuzsanna Szátmari
(Eötvös Loránd University)
The role of the autophagy in a rat model of cerebrovascular stroke
12.00-12.20 ST3 (P3) Viktor Korolchuk (Cambridge University)
Impairment of autophagy also inhibits ubiquitin-proteasome pathway
12.20 - 12.40 ST4 (P4) Matilde Cescon (University of Padova)
Collagen VI signaling in primary neural cell cultures
12.45-16.30 Lunch + Posters
Session II: Autophagy and neurodegenerative disorders
Chair: Ana María Cuervo
16.30 - 17.10 OP4 David Rubinsztein (Cambridge University)
Autophagy upregulation: a possible therapeutic approach for Huntington's disease and related conditions
17.10 – 17.50 OP5 Ralph Nixon (Nathan Kline Institute)
Autophagic-lysosomal dysfunction in Alzheimer's Disease:
A possible target for therapy
17.50 - 18.10 Coffee break
18.10 - 18.50 OP6 Wiep Scheper (AMC University of Amsterdam)
Protein quality control in Alzheimer’s disease
18.50 -19.10 ST5 (P5) Patricia Boya (CIB CSIC)
Cytoprotective role of autophagy after axotomy in vivo
19.10 -19.30 ST6 (P6) Diana Nijholt (AMC University of Amsterdam)
ER stress in Alzheimer's disease: Effects on cellular proteolysis
19.30- 19.50 ST7 (P7) Karen Castillo (University of Chile)
Targeting the autophagy machinery decreases mutant SOD1 aggregation in a cellular model of Amyotrophic Lateral Sclerosis
19.50- 20.10 General discussion
May 6
Session III: Ubiquitin –Proteasome system in neuronal function and pathology
Chair: Ralph Nixon
9.00 - 9.40 OP7 Michael Coleman (The Babraham Institute)
Turnover of Nmnat2 by the ubiquitin proteasome system helps to trigger Wallerian degeneration when axonal transport fails
9.40 - 10.20 OP8 Santiago Rodriguez de Córdoba (CSIC)
Pathogenic mechanisms in Lafora's disease
10.20 - 11.00 OP9 Sarah Tabrizi (University College of London)
Prions and proteasome
11.00 - 11.30 Coffee break
11.30 - 11.50 ST8 (P8) Ralph André (University College of London)
Prions inhibit the ubiquitin-proteasome system by blocking gate-opening and substrate entry into the 20S proteasome
11.50 - 12.20 ST9 (P9) Danny Segal (Tel-Aviv University)
Small quinone-tryptophan molecules rescue Alzheimer's disease model
12.20 - 12.40 ST10 (P10) María E. Figueiredo-Pereira
(Hunter College of City University of New York)
Inflammation and Protein Aggregation: a Missing Link in Neurodegeneration
13.00 - 16.30 Lunch + Posters
16.30 - 17.10 L2 EMBO YI award lecture
Michele Vendruscolo (University of Cambridge)
Life on the edge: Proteins are close to their solubility limits
17.10- 18.00 General discussion
19.00- 21.00 Cultural event
May 7
Session IV: Ubiquitin –Proteasome system and neurodegeneration
Chair: Michael Coleman
9.00 - 9.40 OP10 Ron Kopito (Stanford University)
Why does polyubiquitin accumulate in neurodegenerative disease?
9.40- 10.10 OP11 Nancy Bonini (University of Pennsylvania/HHMI)
Insights from Drosophila as a model for human neurodegenerative disease
10.10- 10.40 OP12 Paul Fraser (University of Toronto)
Neuronal Sumoylation and Its Contributions to Form, Function and Disease
10.40 - 11.00 ST11(P11) Kristian K. Starheim (University of Bergen)
The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation
11.00 - 11.30 Coffee break
11.30 - 11.50 ST12 (P12) José J. Lucas (Centro de Biología Molecular CSIC)
Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery
attributable to aggregate formation
11.50 - 12.10 ST13 (P13) Patricia Maciel (University of Minho)
No evidence for apoptosis or necrosis in spite of Neurodegeneration in a transgenic mouse model of mjd/sca3
12.10 - 12.30 ST14 (P14) Vanesa Fernández-Sáiz
(Technical University of Munich)
Imbalances in p97 cofactor interactions as a molecular basis in human proteinopathy
12.30 - 12.50 ST15 (P15) Tadmiri R. Venkatesh (City College of NY)
Neurodegeneration, temperature sensitive paralysis and life span reduction by targetedactivation of the Ubiquitin ligase,
Anaphase promoting complex (APC) in a subset glia in the Drosophila CNS
12.50 - 14.00 Lunch + Poster removal
Session V: Proteolysis and Neuronal Pathophysiology
Chair: Wiep Scheper
14.30 - 15.10 OP13 Tiago F. Outeiro (Inst. Molecular Medicine)
The UPS and downs of alpha-synuclein in Parkinson’s disease
15.10 - 15.30 ST16 (P16) José G. Castaño
(Autonomous University of Madrid)
Synphilin inhibits alpha-synuclein degradation by the proteasome.
15.30 – 15.50 ST17 (P17) Jeffrey Marblestone (Progenra Inc.)
A novel E3 ligase assay to identify inhibitors of Parkin
15.50 – 16.10 ST18 (P18) Sabine Hilfiker
(Instituto López-Neyra CSIC)
Opposing effects of LRRK2 on autophagosome generation
and autophagic degradation
16.10 – 16.30 Coffee break
16.30 – 17.10 OP14 Keiji Tanaka
(Tokyo Metropolitan Institute of Medical Science)
Autophagic Control of Mitochondrial Homeostasis and Neurodegeneration
17.10 - 18.00 EMBO and ENZO prizes.
General discussion and concluding remarks
Jose G. Castaño /Manuel Rodríguez
21.00 Hrs Gala Dinner
Restaurante “El Rodicio”